Researchers reverse diabetes in mice by infusing them with blood stem cells

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BCH diabetes cell therapyResearchers at Boston Children’s Hospital successfully reversed Type I diabetes in a mouse model using blood stem cells, according to a study published this week in Science Translational Medicine.

The researchers used cells that were pre-treated to make more of a protein, PD-L1, which is deficient in mice and people with Type I diabetes.

“There’s really a reshaping of the immune system when you inject these cells,” senior investigator Dr. Paolo Fiorina said in prepared remarks.

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Researchers tout preclinical results for one-shot vaccination method

Researchers tout preclinical results for one-shot vaccination method

Researchers from Boston Children’s Hospital said today that they achieved strong vaccine responses in preclinical models by adding adjuvants to boost the immune response. The team’s work was published the Journal of Clinical Investigation-Insight and the Journal of Allergy and Clinical Immunology. 

Vaccines have the potential to drastically reduce infant mortality, the researchers said, but newborns often don’t respond optimally because their immune systems produce weak antibody responses. The team wrote that their work could potentially help amplify newborns’ immune response to vaccinations.

Get the full story at our sister site, Drug Delivery Business News.