BIO CEO & Investor Conference Succeeds in Bringing Innovators to Investors and Vice Versa

The 19th Annual BIO CEO & Investor Conference came to a close February 14, having drawn more than 1,225 attendees including nearly 500 investors. During a busy two days, over 2,650 partnering meetings took place arranged through BIO’s One-on-One Partnering™—a proprietary system that enables participants to move efficiently from prospective partner identification to discussion and negotiation. Held at the Waldorf Astoria in New York, the event is one of the largest investor conference focused on established and emerging publicly traded and select private biotech companies who are developing the next generation of medicines and cures.

Beyond bringing investors and companies together for potential collaborations and funding opportunities, the conference featured a wide variety of panel discussions and “fireside chats” with CEOs developing innovative therapies to help patients. Professionals from all areas of biotechnology participated including the investment community, C-level biotech executives, patient advocacy and other non-profit organizations, academics and public policy experts.

There were also more than 160 company presentations from established public and private biotech companies on their latest therapies in development. Rounding out the conference program were video-taped interviews with recognized leaders at the BIO Buzz Center. Click here to view the videos or tune into BIO’s YouTube channel.

BIO sponsors meetings and conferences throughout the year that support industry-wide success including the BIO International Convention which attracts roughly 16,000 attendees from around the globe. This year’s event will be held in San Diego, CA June 19-22.

Partner with Top Asian Biopharma Executives at BIO Asia

On April 8-9, 2014, a diverse group of innovative companies and Japanese dealmakers will come together in a collaborative setting for partnering meetings, company presentations, networking and targeted programming at the 11th annual BIO Asia International Conference.

Japan’s presence as the 2nd largest pharmaceutical industry in the world, bolstered by an evolving Asia-Pacific partnering landscape, means biopharma companies cannot ignore the deal opportunities that are being created in this dynamic market.

Industry leaders have recognized Japan as being ripe with partnership opportunities for biopharma companies this year. Joseph Panetta, president and CEO of Biocom, told Genetic Engineering & Biotechnology News (GEN), “Japan’s moves toward building biopharma appear to give U.S. companies a faster option for expansion into Asia than has been seen after a decade of engagement with China.” Similarly, JP Morgan healthcare specialist Scott Braunstein has touted the direct access that the Japanese pharma landscape has afforded Western companies, saying, “’Many pharma companies have a free run into Japanese markets as it has become so open.”

This kind of participation demonstrates why two days spent at BIO Asia will help your company build the important relationships that are required to succeed in the Asian partnering environment. BIO’s One-on-One Partnering™ system makes this possible by enabling senior executives to arrange private meetings to explore licensing and research collaborations.

BIO Asia also provides a platform for emerging and established innovative Western and Asian biopharma companies to reach new potential partners and tell their story. If you are interested in applying for a company presentation slot, we encourage you to submit your application today. Less than 5 spots remain. See the list of currently confirmed 2014 presenting companies here.

There’s no better time to strengthen your ties with the Japanese biotechnology sector. Additional details about this year’s program, BIO One-on-One Partnering™ and presentation opportunities, as well as registration information, can be found at www.bio.org/bioasia. We look forward to welcoming you to Tokyo!

Find Your Next Asia Partnership in Tokyo at BIO Asia

On April 8-9, 2014, the BIO Asia International Conference will enter its eleventh year. This year, biopharma industry leaders will convene at the Grand Hyatt in Tokyo, Japan to make the cross border deals that will advance collaboration between Asia and the West. This event has become the premier customized partnering event for Western and Asian biopharma executives. According to JP Morgan healthcare specialist Scott Braunstein, Japan has become one of the most critical markets for pharma and biotech firms. Japan currently holds the spot for the second largest pharmaceutical market in the world.

Asian biopharmas at this year’s plenary sessions will include Acucela Inc., TaiGen Biotechnology Co., Ltd., Pfizer (Asia), Baxter (Japan), and Taiwan Liposome Company, Ltd. The speakers and the full descriptions for the 2014 panels can be viewed here. In addition, the following list of Asian biopharma companies will be available for One-on-One Partnering, with more being added daily:

Acucela, Inc.
Allergan Singapore Pte Ltd.
Asahi Kasei Corporation
ASLAN Pharmaceuticals Pte Ltd.
Astellas Pharma, Inc.Baxter
Beijing Fogangren Bio-Pharm Tech, Co., Ltd.
Chugai Pharmaceutical Co., Ltd.
Curadev Pharma Pvt Ltd.
Daiichi Sankyo, Inc.
Dong-A ST
Dr.Reddy’s Laboratories Ltd.
Eddingpharm
Fresenius Kabi Asia Pacific Ltd.
Generon (Shanghai) Corporation
GlaxoSmithKline
Global Health Innovative Technology Fund (GHIT Fund)
Golden Biotechnology Corporation
Hisamitsu Pharma
Hua Medicine
ICS Convention Design, Inc.
Ildong Pharmaceutical Co., Ltd.
JCR Pharmaceuticals Co., Ltd.
Jeil Pharmaceutical
JCR Pharma
JT Pharma
Kissei Pharmaceutical Co., Ltd.
Lilly China Research and Development Co., Ltd.
Lundbeck Research China
Mitsubishi Tanabe Pharma Corporation
Mitsui Chemicals Inc.
MSD K.K.
Nippon Kayaku Co., Ltd.
Ono Pharmaceutical Co., Ltd.
Pluristem Therapeutics, Inc.
ReqMed Company, Ltd.
Sosei Co. Ltd.
TaiGen Biotechnology Co., Ltd.
Taiho Pharmaceutical Co., Ltd.
Taiwan Liposome Company Co., Ltd. (TLC)
Takeda Pharmaceutical Co., Ltd.
Tanaka International, LLC
Tech Manage Corp.
Teva Pharmaceutical Industries Ltd.
Tokyo Stock Exchange, Inc.

There is growing interest in U.S. partnerships by Japanese biopharmas, as evident in several recent deals including Ajinomoto’s $175 million acquisition of San Diego-based Althea Technologies last year. One reason why Japan has become popular among Western biotech and pharma companies is the direct access available in Japan to end markets. Leading biotech companies such as Celgene can sell their products straight into the Japanese market and enjoy overwhelming success.

Registration for the BIO Asia International Conference is open, and BIO’s One-on-One PartneringTM System has launched. Don’t miss this chance to capitalize on the growing opportunities for collaboration available in Asia- register today!

BIO CEO Company Snapshot: Tetraphase Pharmaceuticals

The BIO CEO & Investor Conference is now just a week away, and buzz for the event has never been greater. Tomorrow, Inside BIO is hosting its first ever twitter chat to discuss the annual buyside survey, which has been getting great responses from the investor community. Presentation spots are still sold out as well, and we’re continuing to highlight those companies slated to present. One such company is Tetraphase Pharmaceuticals, who went public this year. Read on to hear about their antibiotic drugs, and what they see in store for them in 2014 and beyond.

tetraphase

 

What is your company’s lead product or technology?

Our lead candidate is eravacycline, a novel, fully synthetic tetracycline antibiotic that has demonstrated potent activity against a broad spectrum of bacteria, including many of the multidrug-resistant (MDR) Gram-negative bacteria highlighted as urgent public health threats by the CDC. We are currently studying the safety and efficacy of eravacycline in two Phase 3 clinical trials in the indications of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI). We expect data from both trials in the first half of 2015 and to file an NDA for eravacycline in the U.S. by the end of 2015.

How does your company go about differentiating itself from the competition?

As a company, Tetraphase is unique amongst its peers, as we have built a product pipeline of novel antibiotics using our internal proprietary antibiotic discovery engine. Our chemistry technology allows for the modification of the tetracycline scaffold in ways never before possible, overcoming resistance and revitalizing the tetracycline class of antibiotics, long considered one of the safest of classes. We believe Tetraphase represents a compelling investment opportunity in the Gram-negative space, given that we are the only public company where successful market entrance offers significant upside potential in valuation. In addition, eravacycline, which was discovered using our technology platform, is the only Gram-negative candidate in late-stage development that has the potential to be used as a monotherapy with convenient once- or twice-daily dosing, and that is expected to be available in both IV and oral formulations.

Your company went public last year. What are your company’s goals and priorities for 2014?

In addition to our IPO last March, we also completed a follow-on offering in November, raising total gross proceeds of approximately $130 million during 2013. With these proceeds, we are currently executing on our Phase 3 clinical program of eravacycline. In mid-2014, we expect to have data from the lead-in portion of the Phase 3 cUTI clinical trial that will identify an oral dose of eravacycline to take into the pivotal portion of the study. We also own worldwide rights to eravacycline – announcements of single or multiple partnerships for development and commercialization rights to eravacycline outside the U.S. are possible during 2014. We continue to make progress on our pipeline as well, and expect to file an IND on our second clinical candidate TP-271, an antibiotic being developed with funding from NIAID to combat serious biothreat pathogens.

Tell us something about your company that investors might not know. 

Those not familiar with the antibiotic space may not know that Tetraphase is benefiting directly from new regulatory guidelines and legislative action. In response to the rise in MDR infections and increased mortality rates and also to encourage the development of new antibiotics, the FDA no longer requires two pivotal studies per indication, permitting companies to file for regulatory approval with two Phase 3 studies in distinct indications. For eravacycline, we will be seeking approval from one Phase 3 study each in cIAI and cUTI. In addition, Tetraphase is benefitting from the GAIN (Generating Antibiotics Incentives Now) Act of 2012. Through the Act, eravacycline has received QIDP (Qualified Infectious Disease Product) designation for both the cIAI and cUTI indications, making it eligible for Fast-Track status, priority review, and an additional five years of U.S. market exclusivity should it ultimately receive FDA approval.

Investors also may not know that eravacycline actually has very broad-spectrum activity – covering not only Gram-negative bacteria, but also Gram-positive and anaerobic bacteria. Although we are pursuing Gram-negative indications currently, eravacycline has some of the most potent activity amongst currently marketed antibiotics against Gram-positive bacteria, including MRSA and VRE.

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Tetraphase’s President and CEO, Guy MacDonald, will be presenting on the second day of the conference, Tuesday, February 11th at 3:00pm in Basildon. You can see the full list of presenting companies here.

Company snapshots are meant to be previews of presentations given at BIO events by way of answering set questions. BIO does not substantiate or validate any claims mentioned in company snapshots or presentations.

BIO CEO Company Snapshot: Conatus Pharmaceuticals

The Company Snapshots have returned for our next One-on-One Partnering event, the BIO CEO & Investor Conference, taking place in New York City this February. The companies that will be profiled in these snapshots will all be presenting at the event, and we hope this provides the opportunity to learn more about them, and catch up on what’s new.

Conatus-Pharma-logo

What is your company’s lead product or technology?

Conatus’s lead product is emricasan, a first-in-class oral medicine designed to reduce inflammation and excessive levels of a specific form of cell death known as apoptosis—two underlying causes of liver damage across a broad spectrum of diseases. Emricasan has been evaluated in over 500 human subjects in six Phase 1 studies completed in healthy volunteers and four randomized, placebo-controlled Phase 2 trials completed in a variety of liver diseases.

How does your company go about differentiating itself from the competition?

Emricasan is a pan-caspase protease inhibitor designed to reduce the activity of all ten human caspases-enzymes that mediate inflammation and apoptosis. Seven caspases are specifically involved in the process of apoptosis while three caspases specifically activate pro-inflammatory cytokines and are not directly involved in apoptosis. We believe that by reducing the activity of these enzymes, emricasan has the potential to interrupt the progression of liver disease regardless of the initial cause. We believe there are no other drugs, either approved or in development, using this mechanism which offers both broad spectrum and self-limiting liver disease activity.

Your company went public last year. What are your company’s goals and priorities for 2014?

Conatus expects top-line results in 1H14 from its ongoing Phase 2b trial in patients with acute-on-chronic liver failure (ACLF), and is planning a Phase 2 trial to initiate in 1H14 in patients with nonalcoholic steatohepatitis (NASH), a Phase 2b trial to initiate in 2H14 in patients with chronic liver failure (CLF), and a Phase 2b trial to initiate in 2H14 in patients who developed liver fibrosis post-orthotopic liver transplant due to hepatitis C virus infection (HCV-POLT), who achieved sustained virus response (SVR) to antiviral therapy, but still have underlying liver fibrosis (HCV-POLT-SVR).

Tell us something about your company that investors might not know.

Emricasan was developed initially by the founders of Idun Pharmaceuticals, who sold the company to Pfizer and founded Conatus in 2005. After further development by Pfizer to prepare the drug to advance to Phase 3 trials and commercialization, Conatus reacquired Idun in 2010 and resumed its development independently.